On AIRR - Immune receptors in the clinic

On AIRR 5: Machine learning and AIRR or Looking for the needle in a needle stack with Dr. Lindsay Cowell and Dr. Victor Greiff

Today we discuss machine learning with Dr. Lindsay Cowell and Dr. Victor Greiff. Machine learning is about pattern recognition and in AIRR-seq the patterns link to diseases and antigen binding. AIRR is nearly a perfect machine learning problem because the underlying patterns are unclear and complex - it is essentially looking for the needle in a needle stack.
Dr. Cowell is from the Biomedical Informatics Division in the Department of Clinical Sciences, UT Southwestern, USA and Dr. Greiff heads  the Laboratory for Computational and Systems Immunology at the Department of Immunology of University of Oslo, Norway.
The episode is hosted by Dr. Ulrik Stervbo and Dr. Zhaoqing Ding.
Comments are welcome to the inbox of onairr@airr-community.org  or on social media under the hashtag #onAIRR. Further information can be found here: https://www.antibodysociety.org/the-airr-community/airr-c-podcast

On AIRR 4: Understanding and engineering immune repertoires with Dr. Jacob Glanville

Dr. Jacob Glanville is founder and CEO of Centivax and  founder of Distributed Bio, acquired by Charles River in 2021. His work focuses on understanding and engineering  the repertoires of T and B cells to improve the response to pathogens. In this episode we discuss how to analyze receptor specificity and use this to create therapeutic antibodies and optimize vaccine response.
AIRR Community Meeting VI: “Exploring New Frontiers”: https://www.antibodysociety.org/the-airr-community/meetings/airr-community-meeting-vi-exploring-new-frontiers
iReceptor+ Seminar Series: http://www.ireceptor-plus.com/news-and-events/seminars
Comments are welcome to the inbox of onairr@airr-community.org or on social media under the hashtag #onAIRR. Further information can be found here: https://www.antibodysociety.org/the-airr-community/airr-c-podcast

On AIRR 3: Outlining chronic lymphocytic leukemia with Dr. Anton Langerak

Anton Langerak is Professor and head of Laboratory Medical Immunology at the Department of Immunology, Erasmus MC in Rotterdam, Netherlands and chair of coordination of the EuroClonality-NGS working group (https://euroclonality.org/ngs/about and https://euroclonality.org). He has been working on chronic lymphocytic leukemia (CLL) for many years and in this episode we discuss the signatures of B cell receptors in CLL.
AIRR Community Meeting VI: “Exploring New Frontiers”: https://www.antibodysociety.org/the-airr-community/meetings/airr-community-meeting-vi-exploring-new-frontiers
Comments are welcome at the inbox of onairr@airr-community.org or on social media under the hashtag #onAIRR. Further information can be found here: https://www.antibodysociety.org/the-airr-community/airr-c-podcast

On AIRR 2: Establishing an AIRR-Seq framework with Dr. Lindsay Cowell

In this episode, we discuss the interest of Lindsay Cowell from UT Southwestern in creating a framework to enable deeper understanding of AIRR-Seq in health and disease.
Comments are welcome at the inbox of onairr@airr-community.org or on social media under the hashtag #onAIRR. Further information can be found here: https://www.antibodysociety.org/the-airr-community/airr-c-podcast/

On AIRR 1: MRD with Dr. Luning Prak

Today's guest is Nina Luning Prak from the University of Pennsylvania. We talk a bit about the AIRR-Community but mostly about diagnosis of B or T cell malignancies and minimal residual disease evaluation and tracking of B cell clones in autoimmunity.
Comments are welcome at the inbox of onairr@airr-community.org or on social media under the hashtag #onAIRR. Further information can be found here: https://www.antibodysociety.org/the-airr-community/airr-c-podcast/